Oiling the Flavivirus replication machinery
نویسندگان
چکیده
منابع مشابه
The haloarchaeal chromosome replication machinery.
The powerful combination of genetic and biochemical analysis has provided many key insights into the structure and function of the chromosomal DNA replication machineries of bacterial and eukaryotic cells. In contrast, in the archaea, biochemical studies have dominated, mainly due to the absence of efficient genetic systems for these organisms. This situation is changing, however, and, in this ...
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OVERVIEW............................................................................................ 650 INTRODUCTION TO FLA VIVIRUS BIOLOGy.............................................. 650 Classification and Life Cycle in Nature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 650 Importance as Disease Agents . . . . . . . . . . . . ....
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Triaryl pyrazoline {[5-(4-chloro-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-phenyl-methanone} inhibits flavivirus infection in cell culture. The inhibitor was identified through high-throughput screening of a compound library using a luciferase-expressing West Nile (WN) virus infection assay. The compound inhibited an epidemic strain of WN virus without detectable cytotoxicity (a 50% eff...
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Flaviviruses are a large group of arboviruses of significant medical concern worldwide. With outbreaks a common occurrence, the need for efficient viral control is required more than ever. It is well understood that flaviviruses modulate the composition and structure of membranes in the cytoplasm that are crucial for efficient replication and evading immune detection. As the flavivirus genome c...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2018
ISSN: 1740-1526,1740-1534
DOI: 10.1038/s41579-018-0050-z